A spokesperson for Greater Manchester Police said :' A man has sadly died following a disturbance in Manchester city centre this evening.
Greater Manchester police ( GMP ) said a "group of people" were involved in the incident on Dantzic Street, near the Printworks leisure venue, to which officers were called on Saturday at just after 8pm.
"A group of people were involved in a disturbance outside and a 60-year-old man suffered an injury and sadly died at the scene.
' A male was arrested on suspicion of murder at the scene and taken to custody where he remains. '
"A cordon is in place and officers are currently at the scene whilst we piece together exactly what happened and who was involved.
superintendent dave kehoe from gmp's serious crime division said : "this was a tragic incident where a 60-year-old has lost his life and our thoughts are with his family and friends who are understandably devastated.
"The area was very busy at the time and a number of people may have seen what happened.
"Even the smallest information could assist with our investigation.
'Information can be reported online at www.gmp.police.uk quoting log 2792 of 20.
Alternatively, contact Crimestoppers anonymously on 0800 555 111."
officers are currently at the scene establishing the timeline of events and following up a number of lines of inquiry regarding what happened, a police spokesman said.
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